Valdemar Grill * Pages 174 - 177 ( 4 )
Latent Autoimmune Diabetes in the Adult, LADA has been investigated less than “classical” type 1 and type 2 diabetes and the criteria for and the relevance of a LADA diagnosis have been challenged. Despite the absence of a genetic background that is exclusive for LADA this form of diabetes displays phenotypic characteristics that distinguish it from other forms of diabetes. LADA is heterogeneous in terms of the impact of autoimmunity and lifestyle factors, something that poses problems to therapy and follow-up, perhaps particularly in those with marginal positivity. Yet, there appears to be clear clinical utility in classifying individuals as LADA.
Autoimmunity, GADA, C-peptide, islet reactive T-cells, type 1 diabetes, type 2 diabetes.
Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, 7006 Trondheim