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Ketoacidosis Due to Empagliflozin, a Paradigm Shift: Case Report and Review of Literature

[ Vol. 15 , Issue. 4 ]

Author(s):

Carlos Hernandez-Quiles*, Nieves Ramirez-Duque and Domingo Acosta-Delgado   Pages 259 - 262 ( 4 )

Abstract:


Introduction: Sodium-glucose cotransporter 2(SGLT2)-inhibitors are new antihyperglycemic agents that have shown a reduction in cardiovascular events in type 2 diabetes mellitus. Recent warnings have been developed about an increased risk of euglycemic and moderate hyperglycemic diabetic ketoacidosis with the use of SGLT2 inhibitors, but its real incidence is not available yet.

Case Report: We present a case of DKA with moderate hyperglycemia in a patient treated with metformin and empagliflozin.

Conclusion: DKA in patients treated with SGLT2 inhibitors can be presented as euglycemic and moderated hyperglycemia. This special presentation poses a physician’s challenge.

Keywords:

Sodium glucose cotransporter 2, SGLT2 inhibitors, empagliflozin, diabetes mellitus, euglycemia , diabetic ketoacidosis.

Affiliation:

Internal Medicine Department, Hospitales Universitarios Virgen del Rocio, Sevilla, Internal Medicine Department, Hospitales Universitarios Virgen del Rocio, Sevilla, Endocrinology Department, Hospitales Universitarios Virgen del Rocio, Sevilla



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