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Molecular and Pathophysiological Mechanisms of Diabetic Retinopathy in Relation to Adhesion Molecules

[ Vol. 15 , Issue. 5 ]

Author(s):

Salini Scaria Joy and Khalid Siddiqui*   Pages 363 - 371 ( 9 )

Abstract:


Diabetic Retinopathy (DR) is considered as a most common microvascular complication of diabetes affected by one in three people who are suffered for diabetes. Several pathophysiological mechanisms and adhesion molecules may play an etiologic role in the development of diabetes and its complications. The adhesion molecules located on both leucocytes and endothelial cells and considered as important molecules which can assessed the endothelial function. The functions of adhesion molecules involved in the cellular margination, slow rolling and transmigration of leukocytes. Hyperglycemia and its immediate biochemical sequelae or the low-grade inflammation directly alter endothelial function or influence endothelial cell functioning indirectly by induce oxidative stress and activates leukocytosis and leukocyte-endothelial cell interactions by the increased expression of adhesion molecules, growth factors, inflammatory factors, chemokines etc. and results DR. This review summarized the several pathophysiological mechanisms and role of adhesion molecules in disruption of homeostasis of vasculature by leukocytes in the development of diabetic retinopathy.

Keywords:

Diabetic retinopathy, endothelial dysfunction, inflammation, leucocytes, integrins, selectins, immunoglobulin superfamily, cadherins.

Affiliation:

Strategic Center for Diabetes Research, College of Medicine, King Saud University, Riyadh, Strategic Center for Diabetes Research, College of Medicine, King Saud University, Riyadh



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