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A Perspective to the Correlation Between Brain Insulin Resistance and Alzheimer: Medicinal Chemistry Approach

[ Vol. 15 , Issue. 4 ]

Author(s):

Navid Rabiee, Mojtaba Bagherzadeh and Mohammad Rabiee*   Pages 255 - 258 ( 4 )

Abstract:


Substantial terms have been recognized on the associated risk elements, comorbidities as well as, putative pathophysiological processes of Alzheimer disease and related dementias (ADRDs) as well as, type 2 diabetes mellitus (T2DM), a few from greatest important disease from the moments. Very much is considered regarding the biology and chemistry of each predicament, nevertheless T2DM and ADRDs are an actually similar pattern developing from the similar origins of maturing or synergistic conditions connected by aggressive patho-corporeal terms and continues to be ambiguous. In this depth-critique article, we aimed to investigate all possibilities and represented a novel and applicable approach from the Medicinal Chemistry concepts.

Keywords:

ADRDs, type 2 diabetes mellitus, human post-mortem, insulin resistance, Alzheimer, medicinal chemistry.

Affiliation:

Department of Chemistry, Sharif University of Technology, Tehran, Department of Chemistry, Sharif University of Technology, Tehran, Biomaterial Group, Biomedical Engineering Department, Amirkabir University of Technology, Tehran



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