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Assessment of Circulating Biomarkers in Relation to Various Stages of Diabetic Retinopathy in Type 2 Diabetic Patients-A Cross Sectional Study

Author(s):

Nalini Mathala*, Annapurna Akula, Sharat Hegde, Raghava Bitra and Virender Sachedev   Pages 1 - 8 ( 8 )

Abstract:


Aim: This study was planned to study the relation between inflammatory markers, and diabetic retinopathy in type II diabetic patients.

Methods: The study was a cross sectional study included 150 type 2 diabetic patients where, divided into 3 groups 50 in each group are divided as Diabetic patients without retinopathy (DM, n=50), non-proliferative diabetic retinopathy patients (NPDR, n=50), proliferative diabetic retinopathy patients (PDR, n=50). All the patients were subjected to complete clinical examination and laboratory investigations such as fasting and postprandial blood glucose, serum creatinine, lipid profile tests, glycosylated haemoglobin (HbA1c), fasting insulin, serum inflammatory markers (TNF-alpha, C-reactive protein) and serum VEGF.

Results: The study revealed that from the multivariate analysis that age, duration and WHR (waist-hip ratio) are potent risk factors responsible for the risk of Diabetic retinopathy. Similarly, serum creatinine, CRP, TNF- alpha and VEGF are significantly higher in diabetic retinopathy with retinopathy compared to diabetic patients without retinopathy.

Conclusion: The study concluded that, inflammation was associated with the severe diabetic retinopathy in patients with well controlled diabetes. A possible relationship was provided between the risk factors and biomarkers which are responsible for Diabetic retinopathy. Hence, modifying the risk factors risk and development of severe diabetic retinopathy can be reduced.

Keywords:

Type 2 diabetes, inflammation, VEGF, TNF- alpha

Affiliation:

Department of Pharmacology, AU College of Pharmaceutical Sciences, Andhra University, Vishakhapatnam, Andhra Pradesh, Department of Pharmacology, AU College of Pharmaceutical Sciences, Andhra University, Vishakhapatnam, Andhra Pradesh, Department of Retina Vitreous Services, L V Prasad Eye Institute, GMR Varalakshmi Campus, Vishakhapatnam, Andhra Pradesh, Department of Pharmacology, AU College of Pharmaceutical Sciences, Andhra University, Vishakhapatnam, Andhra Pradesh, Department of Retina Vitreous Services, L V Prasad Eye Institute, GMR Varalakshmi Campus, Vishakhapatnam, Andhra Pradesh



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