Submit Manuscript  

Article Details


Uncommon Association Between Diabetic Ketoacidosis, Thyrotoxicosis, Cutaneous Abscess and Acute Pericarditis in an Immunocompetent Patient: A Single Case Report and Literature Review

Author(s):

Martinot Amelie, Demar Magalie, Thelusme Liliane, Bounoua Merzaka, Santa Florin, Dueymes Maryvonne, Vujica Jelena, Dequidt Henry and Sabbah Nadia*   Pages 1 - 8 ( 8 )

Abstract:


Introduction: The typical factors precipitating diabetic ketoacidosis (DKA) include infections (30%), cessation of antidiabetic medication (20%), and a new diagnosis of diabetes (25%). The etiology remains unknown in 25% of cases. Less frequent causes cited in the literature include severe thyrotoxicosis and, infrequently, pericarditis. Few publications have described the role of human T lymphotropic virus type 1 (HTLV-1) in endocrine and metabolic disorders. Based on a clinical case associated with several endocrine and metabolic disorders, we suggest a potential role for HTLV-1, an endemic virus in the Amazonian area, and review the literature concerning the role of this virus in thyroiditis, pericarditis and diabetes mellitus.

Case Report: A fifty-year-old Surinamese woman without any medical history was admitted for diabetic ketoacidosis. No specific anti-pancreatic autoimmunity was observed, and the C-peptide level was low, indicating atypical type-1 diabetes mellitus. DKA was associated with thyrotoxicosis in the context of thyroiditis and complicated by nonbacterial pericarditis and a Staphylococcus aureus subcutaneous abscess. The patient was infected with HTLV-1.

Conclusion: To our knowledge, this uncommon association is described for the first time. Few studies have analyzed the implications of HTLV-1 infection in thyroiditis and diabetes mellitus. We did not find any reports describing the association of pericarditis with HTLV-1 infection. Additional studies are necessary to understand the role of HTLV-1 in endocrine and cardiac disorders.

Keywords:

Diabetes mellitus, diabetic ketoacidosis, thyroiditis, acute pericarditis, infection, human T lymphotropic virus type 1.

Affiliation:

Service d’Endocrinologie-Diabétologie Centre Hospitalier Andre Rosemon, avenue des Flamboyants, 97300 Cayenne, Guyane Française, Laboratoire de Biologie, Centre Hospitalier Andre Rosemon, avenue des Flamboyants, 97300 Cayenne, Guyane Française, Service d’Endocrinologie-Diabétologie Centre Hospitalier Andre Rosemon, avenue des Flamboyants, 97300 Cayenne, Guyane Française, Service d’Endocrinologie-Diabétologie Centre Hospitalier Andre Rosemon, avenue des Flamboyants, 97300 Cayenne, Guyane Française, Service de Medecine Interne, Centre Hospitalier Andre Rosemon, avenue des Flamboyants, 97300 Cayenne, Guyane Française, Laboratoire de Biologie, Centre Hospitalier Andre Rosemon, avenue des Flamboyants, 97300 Cayenne, Guyane Française, Service d’Endocrinologie-Diabétologie Centre Hospitalier Andre Rosemon, avenue des Flamboyants, 97300 Cayenne, Guyane Française, Service d’Endocrinologie-Diabétologie Centre Hospitalier Andre Rosemon, avenue des Flamboyants, 97300 Cayenne, Guyane Française, Service d’Endocrinologie-Diabétologie Centre Hospitalier Andre Rosemon, avenue des Flamboyants, 97300 Cayenne, Guyane Française



Read Full-Text article