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Thyroid Dysfunction in Pregnant Women with Gestational Diabetes Mellitus


Shahin Safian, Farzaneh Esna-Ashari and Shiva Borzouei*   Pages 1 - 5 ( 5 )


Aims: Investigation Thyroid dysfunction and autoimmunity in pregnant women with gestational diabetes mellitus.

Background: This article was written to evaluate the thyroid function and anti-thyroid peroxidase (anti- TPO) antibodies in pregnant women with gestational diabetes mellitus (GDM).

Methods: A total of 252 women with GDM and 252 healthy pregnant women were enrolled. Thyroid tests, including TSH, FreeT3, Free T4, and anti-TPO were performed for all women at 24–28 weeks of gestation. Data analysis was then carried out using SPSS ver. 22.

Results: There was a significant difference between the experimental group (38.4%) and the control group (14.06%) in terms of the prevalence of subclinical hypothyroidism (p= 0.016). The frequency of anti-TPO was higher in the experimental group than the control group and positive anti-TPO was observed in 18.6% of women with GDM and 10.3% of healthy pregnant women (P= 0.008).

sion: Thyroid disorders are observed in pregnant women with GDM more frequently than healthy individuals and it may be thus reasonable to perform thyroid tests routinely.


Thyroid diseases, gestational, diabetes, pregnant women, glucose tolerance test, thyroid peroxidase.


Faculty of Medicine, Hamadan University Of Medical Sciences, Hamadan, Associate professor of Community Medicine, Faculty of Medicine, Hamadan University Of Medical Sciences, Hamadan, Department of Endocrinology, School of Medicine, Hamadan University of Medical Sciences, Hamadan

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