Jun Sun, Jie Ji, Yurong Wang and Harvest F. Gu*
Background: China, as the largest developing country in the world, has experienced rapid economic development during the past decades. As a side effect of the rapid growth of Chinese economy, air pollution in the form of haze, is harmful to human health.
Introduction: China is also one of the countries with the highest prevalence of diabetes in Asia and has the largest burden of diabetes in the world. Recent evidence suggests a positive correlation between air pollution and the increased risk of diabetes. However, the association of haze with diabetes is still unclear. Methods Based upon literature searching and study with PubMed, the information of haze and prevalence of diabetes in different cities or provinces of China is summarized. The possible association of haze with diabetes and the perspectives of haze research particularly in prevention of haze in China are then discussed.
Results: The exposure of long-term air pollution such as haze reduced insulin-dependent glucose uptake, leading to insulin resistance; damage beta cell function, leading to decreased insulin secretion, and promote subcutaneous fat accumulation. Pathophysiological effects of particulate matters in diabetes through inflammation and Oxidative stress were evidenced by several epidemiological and experimental studies.
Conclusion: A better understanding of the incidence of diabetes caused by haze exposure may facilitate policy development in air pollution prevention and intervention design in diabetes prevention. Continuous improvement in air quality may help to reduce diabetes prevalence in China.
Air, Environment, Diabetes, Haze, Mechanism, Perspective
Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, 210009 Nanjing, Institute of Environment, Karolinska Institutet, 17177 Stockholm, Center for Pathophysiology, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, 210009 Nanjing, Center for Pathophysiology, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, 210009 Nanjing