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Lifestyle Modification with Physical Activity Promotion on Leptin Resistance and Quality of Life in Metabolic Syndrome - A Systematic Review with Meta-Analysis

Author(s):

Parameshwar Anche, Arun G Maiya*, Shobha Ullas Kamath, B Ananthakrishna Shastry and Ravishankar   Pages 1 - 11 ( 11 )

Abstract:


Objective: The study focused to systematically extract, summarize and analyse the data on the effect of lifestyle modification on leptin resistance and quality of life in metabolic syndrome.

Methods: The systematic search was done using PubMed, Cochrane Database, EMBASE, Science Direct, CINAHL, Springer link, Web of Science from 2000-2018. English language articles, quantitative studies focusing on leptin resistance and quality of life were included. Random effect analysis was adopted to pool data and estimate 95% CI. The meta-analysis was done separately for leptin resistance and quality of life which included a total of 9 studies both RCTs and Non-RCTs.

Results: The meta-analysis of RCTs reported insignificant effect of lifestyle modification on leptin resistance in metabolic syndrome when compared to comparison group [-5.94[-14.28, 2.41]. Two clinical trials showed a significant effect with pooled data [5.52[2.14, 8.91]. Meta-analysis of RCTs focusing on quality of life showed significant effect on mental component [4.89 [0.16, 9.62] of quality of life [2.36 [-3.67, 8.39] when compared to comparison group.

Conclusion: This meta-analysis suggested that lifestyle modification has potential to improve leptin resistance and mental component of quality of life in metabolic syndrome. However, more clearly defined studies are needed to come to a firmer conclusion.

Keywords:

Metabolic Syndrome, Lifestyle modification, Physical activity promotion, Leptin resistance, Quality of life

Affiliation:

Department of Physiotherapy, Centre for Diabetic Foot Care & Research, Manipal College of Health Professions, Manipal Academy of Higher Education, Department of Physiotherapy, Centre for Diabetic Foot Care & Research, Manipal College of Health Professions, Manipal Academy of Higher Education, Department of Biochemistry, Kasturba Medical College, Manipal Academy of Higher Education, Department of Biochemistry, Kasturba Medical College, Manipal Academy of Higher Education, Department of Biostatistics, Prasanna School of Public Health, Manipal Academy of Higher Education



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