Nasser Mikhail* Pages 1 - 4 ( 4 )
Background: Human regular insulin 500 (U-500) is 5 five times more concentrated than traditional regular human insulin (U-100). Thus, each 1 ml of U-500 contains 500 units of insulin as opposed to 100 units/ml with most types of insulin.
Methods: Review of all pertinent clinical studies related to insulin U-500 up to February 12, 2020.
Results: Insulin U-500 is indicated in patients with type 2 diabetes who require more than 200 units of insulin per day. Insulin U-500 has both prandial and basal actions, and can be injected as monotherapy in a convenient twice-daily regimen. Available data suggest that insulin U-500 is effective, associated with better compliance, and decreased injection pain compared with non-concentrated insulins. Its main limitations are hypoglycemia and weight gain, and possibility of dosing errors.
Conclusions: Overall, insulin U-500 is an effective and safe treatment for patients with type 2 diabetes and insulin resistance. Randomized trials are needed to compare longterm efficacy and safety of insulin U-500 with other forms of insulin regimens.
Concentrated insulin U-500, concentrated insulin, pharmacokinetics, pharmacodynamics, efficacy, safety
Olive View-UCLA Medical Center, Endocrinology Division, Department of Medicine, 14445 Olive View Dr. Sylmar, 91342