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Glycemic Variability, Oxidative Stress, and Impact on Complications Related to Type 2 Diabetes Mellitus


Tatiana Valente* and Alberto K. Arbex   Pages 1 - 11 ( 11 )


Chronic hyperglycemia is an established risk factor for the development of complications in both type 1 and type 2 diabetes, but glycemic variability has emerged as a possible independent risk factor for diabetes complications, possibly throughout oxidative stress. In this review we discuss methods to access glycemic variability and oxidative stress, as well as their correlations. We also debate non-pharmacological and pharmacological strategies to achieve a better glycemic control, not only by HbA1c target, but also with reduced glycemic fluctuations, possibly minimizing the risk of diabetes complications.


Glycemic variability, oxidative stress, type 2 diabetes, complications


Division of Endocrinology, Universidade Federal de São Paulo (UNIFESP), São Paulo, IPEMED Medical School/ AFYA Educational, São Paulo

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