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GST T1, M1, and IRS-1 G972R Genetic Variants Association to Gestational Diabetes Mellitus (GDM) in Egyptian women: Linkage to Maternal Hyperglycemia

Author(s):

Naglaa Fathy Barseem*, Essam Khattab, Ragab Dawood and Sally Mohamed  

Abstract:


Background: Gestational diabetes mellitus (GDM) shares in part pathogenic mechanisms of multiple genetic interactions. Some ofT2D susceptibility genes are encountered in association with GDM.

Objective: We aimed to investigate for GST T1, M1 and G972R IRS-I gene polymorphisms with the risk of developing GDM.

Patients and methods: In this randomized case-control study, pregnant women with GDM were genotyped for by PCR analysis for glutathione s-transferase-T1, M1 variant polymorphisms. RFLP was done for the G972R IRS 1 gene. Their newborns were additionally assayed for whole of the clinical, laboratory and genetic aspects.

Results: The T allele, IRS-1rs1801278 TT genotype were frequently detected in GDM mothers in comparison to healthy control ones [for TT homozygous variant; OR(CI 95%): 2.05(1.09-3.87, p: 0.025].Furthermore, GST T1 null was significantly presented in GDM mothers than those of control mother [OR (CI95%: 0.29 (0.084-1.02), p:0.04].Added to the significant correlation of glycemic indices to clinical parameters of infants born to GDM, M1-null genotype of GST was significantly correlated (p<0.05) to abnormal values of respiratory rates and 1 minute-APGAR scores noted for extra NICU care.

Conclusion: Our results suggested GST T1null and IRS-1 TT genotypic variants were claimed for GDM development among Egyptian women with possible impact on their newly born infants.

Keywords:

Gestational diabetes mellitus, maternal hyperglycemia, neonate, GST T, M1, IRS-1.

Affiliation:

Pediatric Department, Faculty of Medicine, Menoufia University, Shebin El-Kom, Biochemistry Department,, Faculty of Medicine, Menoufia University, Shebin El-Kom, Obstetrics & Gynecology Department, Faculty of Medicine, Menoufia University, Shebin El-Kom, Epidemiology& Biostatistics, Preventive Medicine Department, National Liver Institute, Menoufia University



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