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Mean Platelet Volume and Platelet Distribution Width Correlate with Microvascular Complications in Egyptian People with Type 2 Diabetes Mellitus

[ Vol. 17 , Issue. 8 ]

Author(s):

Abd El-Ghany MI*, Nahed Abdallah and Waleed Eldars   Pages 8 - 15 ( 8 )

Abstract:


Background: Type 2 diabetes is a part of metabolic syndrome associated with a higher risk of vascular complications. Diabetes is characterized by changes in platelet morphology, function, and platelet hyperactivity so, it's considered a prothrombotic condition. Morbidity and mortality in people with type 2 diabetes-related to micro and macrovascular complications. Novel biomarkers are needed to identify and treat people at higher risk.

Objective: The main objective of this controlled cross-sectional study was to evaluate Platelet volume indices (PVI) in subjects with type 2 diabetes with and without complications in comparison to subjects without diabetes.

Methods: Hundred and thirty-five subjects aged from 35 to 60 years were subdivided into 3 groups. Group A includes 55 subjects with type 2 diabetes with complications. Group B includes 45 subjects with type 2 diabetes without complications. Group C includes 35 normal healthy subjects. Detailed clinical history was taken. Also, PVI, fasting blood glucose (FBG), hemoglobin A1c, and creatinine were obtained.

Results: Mean Platelet Volume (MPV), Platelet Distribution Width (PDW), Plateletcrit (PCT), and Platelet large cell ratio (P-LCR) were significantly higher among subjects with retinopathy, nephropathy, and neuropathy than other subjects with diabetes who didn't develop complications (P<0.001). At cutoff value > 11.9 fL, MPV have diagnostic sensitivity 80% and specificity 97.8%. Whereas PDW >16.9fL has a sensitivity of 74.5% and specificity of 100% for diabetic microvascular complications (retinopathy, nephropathy, and neuropathy).

Conclusion: MPV and PDW may be considered as possible biomarkers for the early detection of diabetic microvascular complications.

Keywords:

Diabetes, platelet indices, mean platelet volume, platelet distribution width, platelet large cell ratio, microvascular complications.

Affiliation:

Department of Internal Medicine (Endocrinology & Diabetes Unit), Faculty of Medicine, Mansoura University, Mansoura, Department of Physiology at Specialized Medical Hospital, Faculty of Science, Mansoura University, Mansoura, Department of Medical Microbiology & Immunology, Faculty of Medicine, Mansoura University, Mansoura



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