Alok Sharma*, Rakesh Chawla, Jasleen Kaur and Reecha Madaan
Diabetes mellitus is related to unconstrained high blood sugar, and it is linked with long-term impairment, dysfunction, and failure of several organs. Since 1980, the global frequency of diabetes has almost doubled in the adult population. In very rare cases of poor prevention and management programs, diabetes will cause the deteriorated effects on the health and lifespan of the world population, and so on the world economy. Supplements, however, help in the improvement of nutritional deficiencies. Phytotherapeutics has the advantage of being low in cost and easy to access with marginal side effects. So, these are preferred candidates to be used as potential treatment approaches in the management of diabetes. Currently, a multitude of pharmaceuticals is used that is derived from natural compounds having medicinal properties. The mechanistic approach involves regulation of insulin signaling pathways, translocation of GLUT-4 receptors and/or activation of PPAR γ. These natural compounds include numerous flavonoids which help in preventing glucose absorption by preventing the absorption of α-amylase and α-glucosidase. However, to authenticate the efficacy and safety profile of these compounds, detailed validatory clinical studies are required. This review majorly focuses on the mechanistic approaches of various naturally derived compounds relevant in the condition of Diabetes mellitus.
diabetes, phytocompound, antioxidant, natural medicine, management, hyperlipidemia
Department of Pharmacognosy, ISF College of Pharmacy, Moga, University Institute of Pharmaceutical Sciences & Research, Baba Farid University of Health Sciences, Faridkot, Punjab, Department of Pharmacology and Toxicology, NIPER-Kolkata-700054, Kolkata, Chitkara College of Pharmacy, Chitkara University, Punjab, India