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Management of Diabetic Foot Ulcers Using Topical Oxygen Therapy: A Case Series


Sinan F. Tabanjeh*, Talal Al-Malki , Abdulmajeed R Alhazzani and Asirvatham A. Robert  


Background and Aim: Surgical and endovascular revascularization procedures along with hyperbaric oxygen therapy (HBOT) and topical oxygen therapy (TOT) for chronic oxygen-deprived wounds are standard care treatment protocols for diabetic foot ulcer (DFU). Topical developments in the delivery of topical oxygen therapy have made this a more feasible treatment in practice. The present case series highlights the efficacy of NATROX therapy as TOT in wound healing and the impact of increased oxygenation on ulcer healing in patients with diabetic foot ulcers.

Methods: The TOT was evaluated in 6 patients with DFU who have applied NATROX topical oxygen delivery system for a period ranging from 6 weeks to 24 weeks at Kahel Specialized Centre, located in Olaya, Riyadh, Saudi Arabia.

Results: The administration of TOT demonstrated complete wound healing in all the six patients who either had ulcers with minor amputation of toes/heel ulcer or had ulcers other comorbidities with a range from 3 to 8 weeks.

Conclusion: NATROX therapy is an advanced topical oxygen delivery system compared to other conventional oxygen delivery systems; however, the study warrants further research to assess its potential applicability in DFU wound healing in large patients across and across the races.


Diabetic foot ulcers, Diabetes, Hyperbaric Oxygen therapy, Oxygenation Topical oxygen therapy, NATRODiabetic foot ulcers, NATROX


Kahel Specialized Centre, Riyadh, Department of Orthopedics and Trauma, Security Forces Hospital Program, Riyadh, Department of Vascular and Interventional Radiology, King Saud University, Riyadh, Department of Endocrinology and Diabetes, Diabetes Treatment Center, Prince Sultan Military Medical City, Riyadh

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