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Type 2 Diabetes Mellitus and Alzheimer Disease: A Review of the Potential Links

Author(s):

Majid Pakdin, Samaneh Toutounchian, Sina Namazi, Zahra Arabpour, Amirreza Pouladi, Sahar Afsahi, Mohadeseh Poudineh, Mohammad Mehdi Mousavi Nasab, Shirin Yaghoobpoor* and Niloofar Deravi*  

Abstract:


Diabetes mellitus and Alzheimer’s disease are considered the most prevalent diseases in older ages worldwide. The main pathology of Alzheimer’s disease is highly related with accumulation of misfolded proteins that lead to neuronal dysfunction in the brain. On the other hand, diabetes mellitus is associated with alteration of insulin signaling, which could cause the reduction of glu-cose uptake, metabolic prohibition of energy consuming cells, as well as suppression of glucose to fat conversion in the liver. In spite of having seemingly different pathological features, both dis-eases share common underlying biological mechanisms. Besides, the epidemiological and envi-ronmental links between these two diseases should not be overlooked. In this study, we aim to review shared pathological mechanisms of Alzheimer’s disease and diabetes mellitus, including impaired glucose metabolism, increased Amyloid-Beta (Aβ) production, impaired lipid metabo-lism, mitochondrial dysfunction, increased inflammation and elevated oxidative stress. Further-more, we discuss epidemiological/environmental association between these two diseases and also review animal investigations, which have evaluated the potential links between the two diseases.

Keywords:

Alzheimer'ls disease, diabetes mellitus, insulin, drugs, impaired metabolism, inflammation

Affiliation:

Health Policy Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Student's Scientific Research Center, School of Medicine, Tehran University of Medical Sciences, Tehran , Student's Scientific Research Center, School of Medicine, Tehran University of Medical Sciences, Tehran , Department of Nutrition, School of Health, Kerman University of Medical Sciences, Kerman, Student Research Committee, School of Medicine, Shahid Beheshti University of Medi-cal Sciences, Tehran, Student's Scientific Research Center, School of Medicine, Tehran University of Medical Sciences, Tehran Iran 3. Department of Nutrition, Student Research Committee, School of Medicine, Zanjan University of Medical Scienc-es, Zanjan, Student Research Committee, School of Medicine, Shahid Beheshti University of Medi-cal Sciences, Tehran, Student Research Committee, School of Medicine, Shahid Beheshti University of Medi-cal Sciences, Tehran, Student Research Committee, School of Medicine, Shahid Beheshti University of Medi-cal Sciences, Tehran



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