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Consequences of Type 1 and 2 Diabetes Mellitus on the Cardiovascular Regulation During Exercise: A Brief Review

[ Vol. 13 , Issue. 6 ]


Silvana Roberto and Antonio Crisafulli*   Pages 560 - 565 ( 6 )


Introduction: One challenging problem in patients suffering from Diabetes Mellitus (DM) is the elevate incidence of cardiovascular events. Exercise has been proved useful in reducing cardiovascular risks in these patients. However, both type 1 and 2 DM significantly affect the cardiovascular response during exercise. Therefore, on one side exercise is considered to be a valid therapeutic tool for DM, whereas on the other side during exercise these patients may experience troubles in the cardiovascular regulation.

Background: Several impairments at central and at peripheral level have been reported during exercise in both types of DM. For example, sympathetic dysfunctions have been demonstrated in type 1 and 2 DM. Furthermore, impairments in hemodynamics have been often reported. The purpose of the present paper is to briefly review the latest data on the role played by type 1 and 2 DM in the cardiovascular regulation during dynamic exercise.

Conclusion: Hemodynamic dysfunctions may develop in both type 1 and 2 DM during exercise. However, these cardiovascular dys-regulations are different between the two kinds of diabetes.


Blood pressure, cardiac output, exercise pressor reflex, insulin, myocardial contractility, stroke volume, systemic vascular resistance.


Department of Medical Sciences, Sports Physiology Laboratory, University of Cagliari, Cagliari, Department of Medical Sciences, Sports Physiology Lab., University of Cagliari, Via Porcell 4, 09124 Cagliari

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